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THCA vs THC

THCA vs THC: Everything You Need to Know

By Joe Kryszak Published on 02/14/2024

THC is a popular cannabinoid because of its psychoactive effects that could bring benefits. However, not everyone is familiar with THCA, which is another important cannabinoid. THC and THCA are related to each other, but they are not the same.

We’ve prepared this post to help you determine the main difference between THC and THCA.

Are you ready? Let’s begin.

What is THCA?

What is THCA

The full meaning of THCA is tetrahydrocannabinolic acid. It is a non-intoxicating compound abundantly found in raw cannabis plants. However, when smokes THCA becomes THC and will affect the brain and get you high.

Unlike THC, THCA contains an additional carboxyl group (COOH) connected to its chemical chain. This changes the cannabinoid’s molecular structure. The additional molecule prevents THC from binding with cannabinoid receptors in the body and brain.

When you heat up cannabis buds, leaves, or extracts by drying them, a process called decarboxylation happens. This process gets rid of a specific group in the compound and turns THCA into active THC.

Potential Benefits of THCA

THCA, or tetrahydrocannabinolic acid, though non-intoxicating in its raw form, offers a range of potential therapeutic benefits. Research into this cannabinoid is still emerging, but early findings suggest that it may have significant medicinal properties that could support overall health and wellness. Here are some potential advantages of THCA:

  • Anti-Swelling Effects: It may reduce swelling, making it a promising option for conditions related to discomfort.
  • Neuroprotective Properties: Preliminary studies indicate that THCA could protect brain cells and improve cognitive function
  • Supports Healthy Weight: It might help prevent issues related to obesity by regulating metabolism and reducing the risk of related complications.
  • Anti-Nausea Benefits: THCA demonstrates potential in reducing nausea and improving appetite.
  • Antioxidant Activity: It may help in fighting oxidative stress in the body, protecting cells, and promoting overall longevity.

These potential benefits highlight THCA’s therapeutic promise, warranting further research to uncover its full capabilities.

What is THC?

What is THC

Tetrahydrocannabinol, commonly referred to by its abbreviation THC, is the main psychoactive compound derived from the cannabis plant. It is responsible for producing heightened sensory effects, which we normally call “high.”

When consumed through methods like smoking, vaping, edibles, or tinctures, THC mimics the body’s own endogenous cannabinoids. It is able to bind with cannabinoid receptors in the brain and central nervous system.

This interaction allows it to change normal communication pathways. As an outcome, users experience the famous high (or altered perception of time) associated with marijuana use.

But when used responsibly, THC provides enjoyable and even therapeutic effects to recreational and medical users alike.

Potential Benefits of THC

Tetrahydrocannabinol (THC) is known for its psychoactive properties, but its potential health benefits for both recreational and medical users make it a valuable compound. Below are some of the key potential benefits of THC:

  • Alleviate Discomfort: It interacts with the endocannabinoid system to provide fast relief and help with soreness.
  • Appetite Stimulation: Known as the “munchies,” THC effectively stimulates appetite, which can assist individuals dealing with weight loss or nutritional deficiencies.
  • Nausea and Vomiting Reduction: It has been widely used to alleviate nausea and vomiting.
  • Improved Sleep: It promotes relaxation and muscle relief, which can help individuals with sleeping difficulties.
  • Mood Enhancement: Small doses of THC may alleviate feelings of sadness or stress, helping to improve overall mood and mental well-being.

The therapeutic potential of THC continues to be studied, offering promising applications for various health conditions.

THCA and THC Forms

In this section, we’ll explore the various forms of THCA and THC, to give a comprehensive understanding of how these compounds are consumed.

THCA Forms

THCA is the non-psychoactive precursor to THC, offering its unique potential benefits in diverse forms:

  • Raw Cannabis: THCA is most commonly found in fresh, raw cannabis that hasn’t undergone any heating process. This form is non-intoxicating.
  • THCA Isolates: These are highly refined THCA concentrates, often used for precise dosing or therapeutic purposes.
  • THCA Tinctures and Edibles: THCA-infused products, often consumed as dietary supplements for potential health benefits without psychoactive effects.

THC Forms

THC, the psychoactive cannabinoid produced when THCA is decarboxylated (heated), is available in a variety of forms:

  • Smokable Products (Flower and Concentrates): THC is present in combusted or vaporized cannabis, creating psychoactive effects.
  • THC Edibles: Infused foods and beverages that deliver THC through digestion for longer-lasting effects.
  • THC Oils and Vapes: Concentrated THC for use in vape pens or oil-based products, offering fast absorption and customizable dosing.

Key Differences Between THCA and THC

Psychoactive Effects

THCA (tetrahydrocannabinolic acid) and THC (tetrahydrocannabinol) are two closely related compounds naturally present in cannabis. Despite their similarity, they significantly differ in their chemical composition, psychoactive properties, physiological effects, legal regulation, and natural occurrence within the cannabis flower.

  • Chemical Structure: THCA is the acidic precursor of THC and contains a carboxyl group, which renders it non-psychoactive. Through heat exposure (decarboxylation), THCA loses this carboxyl group, converting into THC and becoming psychoactive.
  • Psychoactive Effects: THC is known for its strong psychoactive effects, which produce feelings of euphoria or a “high”, due to its binding affinity with the CB1 receptors in the brain. In contrast, THCA does not directly bind to these receptors and therefore does not induce a noticeable psychoactive experience while remaining in its acidic form.
  • Body Effects: THCA is associated with potential therapeutic effects, showing anti-swelling, neuroprotective, and antiemetic qualities without an intoxicating sensation. THC also has therapeutic benefits such as alleviating discomfort, appetite stimulation, and sleep promotion, but these come accompanied by psychoactive experiences.
  • Legal Status: In most legal jurisdictions, THC is strictly regulated or classified as an illegal and controlled substance due to its psychoactive and intoxicating properties. Meanwhile, THCA often has ambiguous legal status or is considered lawful, as regulations frequently differentiate between psychoactive cannabinoids and non-psychoactive precursors or acids.
  • Presence in Cannabis Flowers: Fresh cannabis flowers predominantly contain THCA rather than THC, due to the plant’s biosynthesis pathway. THC is produced when THCA-rich cannabis flower undergoes heating, drying, and curing processes, thus converting much of the acidic cannabinoid into its psychoactive form.

THCA vs Delta 8

While THCA is a non-psychoactive compound found in raw cannabis that converts to THC through heat, Delta 8 is a psychoactive cannabinoid derived from hemp. Delta 8 binds with CB1 receptors, delivering a mild high, whereas THCA provides therapeutic benefits like anti-inflammatory properties without intoxication. THCA vs Delta 9 offers another perspective regarding the unique benefits and psychoactive differences between these two cannabinoids.

The Conversion Process of THCA to THC

The transformation of THCA (tetrahydrocannabinolic acid) to THC (tetrahydrocannabinol) occurs through a chemical reaction known as decarboxylation. This process is key to unlocking the psychoactive properties of cannabis. In its natural state, THCA is abundant within raw cannabis leaves and flowers and remains non-intoxicating due to its additional carboxyl group (COOH). However, when cannabis is exposed to heat or aging, the carboxyl group detaches, converting THCA into THC. This reaction is triggered when cannabis is smoked, vaporized, baked, or subjected to prolonged heat during extraction.

For example, lighting up cannabis causes rapid decarboxylation, changing THCA into THC instantly and delivering intoxicating effects almost immediately. Similarly, baking cannabis products, such as edibles, prompts the decarboxylation process at lower, controlled temperatures over time, ensuring THCA fully converts into THC. Without this conversion, cannabis consumption remains non-psychoactive, as unheated THCA cannot bind effectively with cannabinoid receptors in the brain and body. Thus, decarboxylation is a vital step for individuals seeking the sensory-altering effects of THC.

Consumers often explore concentrate options, and understanding live resin vs rosin vs distillate provides valuable insight into the differences in cannabinoid profiles and the effects achieved through heating or processing. This process is key to unlocking the psychoactive properties of cannabis.

Consumption Methods

Can You Consume THC and THCA

THC and THCA can be consumed through multiple methods, each providing distinct advantages and experiences. These options range from traditional smoking and vaping to innovative methods like edibles, sublingual, and topical products. Understanding their differences helps users select the best method suited to their personal needs.

  • Sublingual Products:
    • Sublingual consumption involves placing THC or THCA oils under the tongue for rapid absorption directly into the bloodstream, resulting in quick and reliable effects.
    • THCA oil retains its non-psychoactive state, offering therapeutic benefits without impairment, whereas THC oil provides sensory-enhancing and recreational psychoactive effects.
  • Topical Products:
    • Topicals such as creams, lotions, and balms deliver THC and THCA directly to the skin and effectively provide localized relief without systemic effects.
    • THCA remains non-psychoactive due to lack of heat-induced conversion, and THC only minimally absorbs into the bloodstream, making topical application ideal for consumers seeking relief without intoxication.
  • Smokable Products:
    • Smoking and vaporizing cannabis allows THC to absorb rapidly through lung tissue, bringing quick onset psychoactive effects within minutes.
    • While smoking causes harsh smoke inhalation and potential respiratory irritants, vaporization produces cleaner vapor, bypassing combustion and reducing exposure to carcinogens.
  • Edible Products:
    • These encompass foods, beverages, capsules, and tinctures, and can provide extended cannabinoid effects lasting 4-12 hours; however, the onset is slower (30-90 minutes).
    • The delay in effects poses a risk of overconsumption, but edibles effectively maintain steady cannabinoid levels, beneficial for prolonged relief without frequent re-dosing.

THC and Research

THC’s Role in Reducing Ongoing Discomfort

Discomfort that lasts for a long time diminishes one’s quality of life. This may include different types of discomfort that stem from various medical conditions. Emerging research studies discovered that THC may provide relief from recurring pain.

Scientists think THC works by binding to natural cannabinoid receptors in the body that are part of the endocannabinoid system. This system is involved in pain signals and other processes. When THC activates these receptors, it may reduce the intensity and perception of discomfort that patients experience.

More studies are still needed to confirm, but using THC products like certain oils, edibles, or pills shows promise in helping people find daily relief from sources of constant pain.

THC and Appetite

A well-known effect of consuming cannabis is experiencing the “munchies” effect. This is the feeling wherein the user feels very hungry and wants to eat a lot. This happens because THC interacts with parts of the brain that control hunger signals.

While munchies might not always be fun, this appetite-boosting effect could actually help some individuals who have lost the desire to eat.

Certain illnesses and medical treatments can leave people with poor appetite. Such a condition causes weight loss and poor nutrition.

Early clinical research shows that THC’s ability to make people hungry may help increase appetite and calorie intake for such patients. By stimulating the desire to eat, THC can support patients in eating more regular, nutritious meals.

THC and Sleep

Getting good sleep is important for health. Some early studies suggest that THC could act as a sleep aid.

Because THC can interact with brain receptors that influence body relaxation and stress levels, by lessening the stress levels and relaxing tired muscles, THC may help some people fall asleep more easily at night.

A small study found that a dose of THC before bed helped reduce the time it took people to fall asleep. And they reported better sleep quality compared to a placebo. THC also appeared to improve breathing during sleep in those with breathing impairments. If you’re looking for an effective way to integrate THC into your nighttime routine, Stirling Delta 8 Sleep Gummies and Delta 9 Sleep Gummies are excellent solutions.

THC and Relaxation

Feeling down? Some early research found that appropriate doses of THC can improve sadness and irritability. Thus, THC may help some people become more relaxed.

A few small studies found people reported improved mood and less distress over several weeks when taking regular THC doses under medical supervision. The right amount helped buffer emotional stress.

Though more research is still needed, using THC as part of a mental health plan shows initial promise for low mood.

THCA and Research

THCA and Healthy Weight

Excess weight and obesity take a major toll on our bodies over time. Certain unhealthy medical conditions may start to develop if overweight is not addressed. An interesting study in 2020 found that THCA may help prevent this health issue.

Researchers tested the effects of THCA on a test subject consuming very fatty diets to mimic obesity. What they discovered was that the test subjects getting regular doses of THCA didn’t become diabetic or struggle with liver trouble nearly as much as those without.

Potential Anti-Swelling Effects

Ongoing redness, swelling, and tenderness in the body lead to general discomfort. Things such as muscle pain or even joint discomfort may cause the mentioned symptoms.

Early lab research shows promise that THCA, the raw form of THC from marijuana, may actually lower some of these discomforts. Tests show THCA can calm overactive immune responses and reduce swelling pathways.

While human trials are still required, THCA demonstrates the potential to provide certain therapeutic benefits related to intense soreness and irritation issues.

Potential Brain-Protective Effects

Our brains control everything we do. Losing brain cells over time leads to memory loss and confusion. However, some interesting research shows that THCA, a precursor cannabinoid, may actually offer some neuroprotective properties.

Specific tests have been done, showing that regular doses of THCA could prevent brain cell damage and death. Those consuming THCA for just a few weeks had much better thinking ability and less loss of brain function compared to those who didn’t get the treatment.

Researchers became convinced that THCA can strengthen brain channels that normally decline with age. The cannabinoid with cannabinoid acid seems to shield delicate nerve pathways from wearing down over time.

The Moment of Truth: THCA or THC

Deciding between THCA vs THC depends greatly on one’s personal body chemistry and wellness goals.

THC, the famous cannabinoid of them all, produces the classic cannabis “high” as it interacts with specific receptors in the brain and body. This time-altering effect provides recreational and therapeutic benefits such as relaxation, pain relief, and improved sleep. However, there are certain side effects that accompany THC usage – lack of coordination, dry mouth, and red eyes.

In contrast, THCA does not produce psychoactive effects. It only indirectly activates cannabinoid receptor 1 (CB1). So while it does not create a mental “high,” THCA still reduces swelling, protects brain cells, and improves appetite. THC generates a vibrant but unpredictable experience that some find very rewarding.

You should not also forget that there are more research studies conducted on psychoactive THC, meaning many scientists better understand it. THCA may still be considered a new player, and how it really works inside the body is still unclear.

In summary – those seeking to enrich activities with a euphoric mood boost may choose THC’s recreational and therapeutic capacities. This is recommended once the proper personal dosage is determined.

THCA’s stability and unique actions could prove the wiser choice for others interested solely in non-intoxicating wellness advantages.

What to look for when buying THC and THCA products?

What to look for when buying THC and THCA products

When purchasing THC and THCA products, consumers should carefully evaluate several factors to ensure quality, safety, and legality. Given the wide variety of available products, informed decisions can help individuals select safe and suitable products tailored to their preferences and needs.

  • Product Source and Reputable Brands: Consumers should purchase THC and THCA products from trustworthy, reputable sellers or companies with established positive reputations. Reliable brands typically provide transparency regarding sourcing, extraction processes, and accurate cannabinoid content, protecting consumers from inferior or unsafe products.
  • Lab Testing and Certification: It’s essential to look for THC and THCA products that have undergone third-party laboratory testing to confirm potency, purity, and ensure the absence of contaminants like heavy metals, pesticides, and residual solvents. Verified lab reports are usually readily accessible via QR codes or brand websites, ensuring consumer safety and product integrity.
  • Method of Extraction and Manufacturing: Consumers should consider how THC and THCA are extracted and processed, as extraction methods directly affect purity and quality. Methods such as CO2 extraction or solventless extraction (like rosin) are preferred because they typically result in cleaner, safer products compared to solvent-based extraction techniques.
  • Cannabinoid Concentration and Dosing Information: Clearly defined cannabinoid profiles and concentration details allow consumers to accurately determine dosage and predict product effects. THC and THCA potency should be explicitly noted on product packaging to help users choose products aligned with their experience level and desired outcomes.
  • Legal Compliance and Local Regulations: Buyers should be familiar with their local and regional legal guidelines concerning THC and THCA products. Ensuring the product complies with legal THC limits according to the consumer’s location helps individuals stay informed and protected from potential legal complications.
  • Consumer Reviews and Personal Recommendations: Checking online consumer reviews and seeking personal recommendations can help identify consistently reliable products and avoid those that may pose quality or efficacy issues. Published consumer experiences offer practical insights into the product’s effectiveness, reliability, and potential side effects.

Frequently Asked Questions

How is THCA converted to THC?

THCA transforms into THC through a chemical reaction called decarboxylation. This is activated by heat or aging in the cannabis plant. Initially, when cannabis is harvested, it has THCA with minimal THC content. Decarboxylation happens when the cannabis plant is exposed to heat (e.g., smoking, baking, or vaping). During this process, the THCA molecule loses a carboxyl group, turning it into THC. This activation enhances the psychoactive properties of THCA.

Is THC legal?

THCA is legal in most states and countries. This treatment is explained by the fact that THCA does not produce psychoactive effects typically related to cannabis usage. THCA is also almost legal if it is derived from hemp plants, as indicated by the provisions of the 2018 Farm Bill. THC’s legal status depends on the laws of a specific country or state. Some places allow the use of THC for medical or recreational use. In some places, it is completely banned. In the USA, one can possibly access THC-rich products such as Delta 9 Gummies or Delta 8 Sleep Gummies. The condition is that the THC is obtained from industrial hemp plants.

How long do the effects of THC and THCA typically last?

The duration of these cannabinoids’ effects varies. For THC: Typically, THC’s impact may become noticeable within minutes to an hour following consumption. How long will it last? Based on users’ experience, it can generally last from 4 – 6 hours. For THCA: When consumed in its raw and unheated form, THCA does not produce immediate effects. THCA requires decarboxylation, a process involving heat, to convert into THC and induce the characteristic effects associated with cannabis consumption. Therefore, THCA’s effects depend on the subsequent conversion to THC.

Can THC and THCA appear in drug tests?

Yes, both cannabinoids may be detected by a standard drug test. Traditional drug tests are designed to identify the presence of THC and its metabolites (TCHA is one of them).

How Long Does THCA Stay in Your System?

THCA is generally detectable in the body for one to two days after a single use, but regular or heavy use can extend this detection window to weeks or even months due to its accumulation in fatty tissues. Detection times also vary based on the testing method: urine tests can detect it for several days to weeks, while hair tests may reveal traces for months.

How Long Does THC Stay in Your System?

THC detection lasts three to seven days in urine for moderate users, up to 30 days for heavy users, and a few hours to two days in the bloodstream. Hair testing can detect THC use for up to 90 days, but individual factors like metabolism, body fat percentage, and frequency of use influence elimination times.

Is THC or THCA Stronger?

THC is stronger in terms of psychoactive effects, as it binds directly to CB1 receptors in the brain, creating a “high.” THCA is non-psychoactive in its raw form but holds therapeutic potential, offering benefits like reducing soreness without intoxication.

About the Author

A leader in the Hemp Industry since 2014, Joe has been at the forefront of the Hemp Industry's innovation and growth. He is passionate about creating an atmosphere of collaboration and education in the Hemp Industry through the growth of Stirling Oils. Prior to this, Joe led strategic growth teams and initiatives at HP, Lenovo, and Amazon. With a degree from SDSU and an MBA from Pepperdine, Joe guided numerous businesses beyond the $1B threshold.